Scientific Publications & Presenations
2025
A novel CD71 Centyrin:Gys1 siRNA conjugate reduces glycogen synthesis and glycogen levels in a mouse model of Pompe disease
Nonclinical Studies in Non-Human Primates on ABX-1100:
A Centyrin:Gys1 siRNA Conjugate for the Treatment of Pompe Disease
PRESENTATION: A novel Centyrin:siRNA targeting and delivery platform inhibits glycogen synthesis and reduces glycogen levels in skeletal and cardiac muscle in a mouse model of Pompe disease
POSTER: Centyrin-targeted glycogen synthase-1 siRNA conjugates: A novel, muscle targeted glycogen reduction therapy for the treatment of Pompe Disease
PRESENTATION: Centyrin-targeted glycogen synthase-1 siRNA conjugates: A novel, muscle targeted glycogen reduction therapy for the treatment of Pompe Disease
2024
POSTER: Nonclinical Studies in Non-Human Primates on ABX-1100:
A Centyrin:Gys1 siRNA Conjugate for the Treatment of Pompe
POSTER: A novel Centyrin:siRNA targeting and delivery platform inhibits glycogen synthesis and reduces glycogen levels in skeletal and cardiac muscle in a mouse model of Pompe disease
PRESENTATION: A novel Centyrin:siRNA targeting and delivery platform inhibits glycogen synthesis and reduces glycogen levels in skeletal and cardiac muscle in a mouse model of Pompe disease
POSTER: Centyrin-targeted glycogen synthase-1 siRNA conjugates: A novel, muscle targeted glycogen reduction therapy for the treatment of Pompe Disease
PRESENTATION: Centyrin-targeted glycogen synthase-1 siRNA conjugates: A novel, muscle targeted glycogen reduction therapy for the treatment of Pompe Disease
2021 Molecular Therapy Publication
Centyrin ligands for extrahepatic delivery of siRNA
Authors: Donna Klein, Shalom Goldberg, Christopher S. Theile, Richard Dambra, Kathleen Haskell, Elise Kuhar, Tricia Lin, Rubina Parmar, Muthiah Manoharan, Mark Richter, Meizhen Wu, Jeannine Mendrola Zarazowski, Vasant Jadhav, Martin A. Maier, Laura Sepp-Lorenzino, Karyn O’Neil, and Vadim Dudkin
2020 RAS Europe Poster Presentation
Bispecific Centyrin – panKRAS siRNA conjugate with anti-proliferative activity in KRAS mutant tumor cell lines
Authors: Robert Kolakowski, Russell C. Addis, Swapnil Kulkarni, Joshua Gorsky, Rebecca Meyer, Yao Xin, Evana Mortezavi, Evan Greenawalt, Karyn T. O’Neil, Steven G. Nadler
2017 Bioconjugate Chemistry
Evaluation of a Centyrin-Based Near-Infrared Probe for Fluorescence-Guided Surgery of Epidermal Growth Factor Receptor Positive Tumors
Authors: Sakkarapalayam M. Mahalingam, Vadim Y. Dudkin, Shalom Goldberg, Donna Klein, Fang Yi, Sunil Singhal, Karyn T. O’Neil and Philip S. Low
2014 Protein Engineering, Design & Selection
Selection of high-affinity Centyrin FN3 domains from a simple library diversified at a combination of strand and loop position
Authors: Michael D. Diem, Linus Hyun, Fang Yi, Randi Hippensteel, Elise Kuhar, Cassandra Lowenstein, Edward J. Swift, Karyn T. O’Neil and Steven A. Jacobs