Scientific Publications & Presenations
2022 TIDES USA Conference
Centyrin-targeted siRNA conjugates demonstrate potential new therapeutic approach for reduction of skeletal muscle glycogen in Pompe disease
Authors: Aro Biotherapeutics
2022 ELRIG Conference
Creating A New Class of Centyrin - Oligonucleotide Therapeutics
Authors: Aro Biotherapeutics
2022 3rd RNAi-Based Therapeutics Summit
Creating a New Class of Receptor Targeted Genetic Medicines
Authors: Aro Biotherapeutics
2022 Muscular Dystrophy Association Conference Poster
Extra-hepatic delivery of Centyrin-targeted oligonucleotides
Authors: Rebecca Meyer
2021 Oligonucleotides Therapeutics Society Meeting
Creating a New Class of Receptor Targeted Genetic Medicines
Authors: Aro Biotherapeutics
2021 Molecular Therapy Publication
Centyrin ligands for extrahepatic delivery of siRNA
Authors: Donna Klein, Shalom Goldberg, Christopher S. Theile, Richard Dambra, Kathleen Haskell, Elise Kuhar, Tricia Lin, Rubina Parmar, Muthiah Manoharan, Mark Richter, Meizhen Wu, Jeannine Mendrola Zarazowski, Vasant Jadhav, Martin A. Maier, Laura Sepp-Lorenzino, Karyn O’Neil, and Vadim Dudkin
2020 RAS Europe Poster Presentation
Bispecific Centyrin – panKRAS siRNA conjugate with anti-proliferative activity in KRAS mutant tumor cell lines
Authors: Robert Kolakowski, Russell C. Addis, Swapnil Kulkarni, Joshua Gorsky, Rebecca Meyer, Yao Xin, Evana Mortezavi, Evan Greenawalt, Karyn T. O’Neil, Steven G. Nadler
2020 AACR Poster Presentation
Tumor-targeted knockdown of KRAS mutants with novel Centyrin: siRNA conjugates
Authors: Robert Kolakowski, Russell C. Addis, Swapnil Kulkarni, Joshua Gorsky, Rebecca Meyer, Yao Xin, Evana Mortezavi, Evan Greenawalt, Karyn T. O’Neil, Steven G. Nadler
2020 Oligonucleotide Society 2020 meeting
Tumor Targeted Knockdown of KRAS mutants with novel Centyrin: siRNA conjugates
Authors: Robert Kolakowski, Russell C. Addis, Swapnil Kulkarni, Joshua Gorsky, Rebecca Meyer, Yao Xin, Evana Mortezavi, Evan Greenawalt, Karyn T. O’Neil, Steven G. Nadler
2019 AACR Poster Presentation
ABX9xx: A multi-specific Centyrin that synergizes to attenuate intracellular signaling in cMET/EGFR positive tumor cells
Authors: Russ Addis, Robert Kolakowski, Swapnil Kulkarni, Josh Gorsky, Rebecca Meyer, Yao Xin, Steve Nadler, Karyn O’Neil
2017 Bioconjugate Chemistry
Evaluation of a Centyrin-Based Near-Infrared Probe for Fluorescence-Guided Surgery of Epidermal Growth Factor Receptor Positive Tumors
Authors: Sakkarapalayam M. Mahalingam, Vadim Y. Dudkin, Shalom Goldberg, Donna Klein, Fang Yi, Sunil Singhal, Karyn T. O’Neil and Philip S. Low
2016 Protein Engineering, Design & Selection
Engineering a targeted delivery platform using Centyrins
Authors: Shalom D. Goldberg, Rosa M.F. Cardoso, Tricia Lin, Tracy Spinka-Doms, Donna Klein, Steven A. Jacobs, Vadim Dudkin, Gary Gilliland and Karyn T. O’Neil
2014 Protein Engineering, Design & Selection
Selection of high-affinity Centyrin FN3 domains from a simple library diversified at a combination of strand and loop position
Authors: Michael D. Diem, Linus Hyun, Fang Yi, Randi Hippensteel, Elise Kuhar, Cassandra Lowenstein, Edward J. Swift, Karyn T. O’Neil and Steven A. Jacobs
2012 Protein Engineering, Design & Selection
Design of novel FN3 domains with high stability by a consensus sequence approach
Authors: Steven A.Jacobs, Michael D. Diem, Jinquan Luo, Alexey Teplyakov, Galina Obmolova, Thomas Malia, Gary L. Gilliland and Karyn T. O’Neil